May 11, 2016 at 12:15 PM

University of Sheffield/MedImmune Collaborative PhD Studentships 2016 in Synthetic Biology Platform Development for Biopharmaceutical Manufacturing

Applications are invited for two 3.5 year research studentships at the University of Sheffield in partnership with MedImmune Ltd. The students will join a team of researchers at Sheffield and MedImmune engaged in the development of a synthetic biology based platform for multi-component genetic engineering of Chinese Hamster Ovary (CHO) cell factories.

Students will be based in Sheffield and have direct access to a large range of laboratory facilities and expertise within the Advanced Biomanufacturing Centre at the Dept. of Chemical and Biological Engineering.  Sheffield has a comprehensive, formal Doctoral Development Programme for all postgraduate students.  This is a flexible, ongoing training plan that is an integral part of the research degree, and is tailored to the students’ individual needs. It helps progression through research studies by a full Training Needs Analysis tailored to the student, providing opportunities to acquire new skills and experience.

The MedImmune site at Cambridge comprises over 450 employees and is MedImmune’s primary European research centre, focusing on discovery and development of novel biopharmaceutical products across multiple therapeutic areas: infection; oncology; respiratory, inflammation and autoimmunity; neuroscience and cardiovascular / gastrointestinal. The student will have the opportunity to meet and interact with a wide variety of scientists, including other students, as well as more senior scientists across a range of disciplines.  MedImmune encourages cross-disciplinary and cross-departmental communication and collaboration. The student will be encouraged to attend and present at internal seminars, both within the department and the broader company, as well as attend seminars given at MedImmune by invited external speakers.  The student will benefit from the state-of-the-art research and development laboratory facilities at MedImmune.  At a practical level this will include exposure to bioprocessing performed in an industrial setting and will provide a greater insight into the product development process.Benefits to the Student

These studentships attract an enhanced stipend and will provide access to training, facilities and expertise not available in an academic setting alone.  Students have an opportunity to develop a range of valuable skills and significantly enhance their future employability.  Many students will become bioindustrial or research leaders of the future.  

Applicants should have, or expect to receive a good honours degree (2/1 or 1st class) in bio(chemical) engineering or a molecular biosciences subject.

Project title 1
Development of a high throughput analytical platform for the characterisation of biopharmaceuticals generated from multi-gene engineered CHO cells

Primary and secondary supervisors Prof Mark Dickman and Prof David James

Project title 2
Genome-scale dissection of secretory pathway function for protein product specific CHO cell engineering

Primary and secondary supervisors Professor David James and Dr Andrew Peden

To apply please contact in the first instance

Date posted 11th May 2016