What did you do at Sheffield?

I joined Sheffield in 2007 as a Postdoctoral Research Associate to work on a 3 year project to develop a model of recombinant monoclonal antibody synthesis in Chinese hamster ovary (CHO) cells, the current workhorse for the manufacture of therapeutic proteins by the biopharmaceutical industry. This novel project involved combining mathematical modelling and molecular biology to understand why some cell lines work better than others. This was a fantastic opportunity for me to start my career as a scientific researcher, and the project gave me lots of opportunities to learn cutting edge research methods and techniques under the supervision of Professor David James. One of the main attractions of the project was the close association with the biopharmaceutical industry. The project was sponsored by the BBSRC Bioprocessing Research Industry Club (BRIC) in association with Lonza Biologics, a leading contract manufacturer of therapeutic proteins. This gave me access to industrial facilities and knowledge, which I could not have acquired in any other way. The project also gave me fantastic networking opportunities and the chance to speak with both industrialists and academics from all over the world at conferences and other events. In 2010 I then moved to another project in Professor David James’s lab, this time to look at mechanisms of genetic instability of CHO cells, and sponsored by Pfizer.